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This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms. Discussion of the clinical implications of pathological findings is contributed by renowned clinicians in the field. This handsome volume guides the reader through the intricacies of genitourinary tumor pathology, diagnosis, reporting, and prognosis. Written by experts in the field, Genitourinary Pathology: Practical Advances is of great value to anatomic pathologists, urologists, fellows in genitourinary pathology, as well as upper level residents training in pathology. Cristina Magi-Galluzzi, MD, PhD The Cleveland Clinic Department of Pathology Robert J Tomsich Pathology and Laboratory Medicine Institute Cleveland, OH, USA Christopher G. Przybycin, MD The Cleveland Clinic Department of Pathology Robert J Tomsich Pathology and Laboratory Medicine Institute Cleveland, OH, USA Part I:  Update on Prostate Tumor Pathology   1: Anatomy of the Prostate Revisited: Implications for Prostate Biopsy and Zonal Origins of Prostate Cancer Samson W. Fine and Rohit Mehra   2: Contemporary Gleason Grading System Kiril Trpkov   3: Contemporary Prostate Cancer Staging Christopher G. Przybycin, Sara M. Falzarano, and Cristina Magi-Galluzzi   4: Prostate Cancer Reporting on Biopsy and Radical Prostatectomy Specimens Samson W. Fine     5: Unusual Epithelial and Non-Epithelial Neoplasms of the Prostate Adeboye O. Osunkoya and Cristina Magi-Galluzzi   6: Management Implications Associated with Unusual Morphologic Entities of the Prostate Viraj A. Master, Jonathan Huang, Cristina Magi-Galluzzi, and Adeboye O. Osunkoya   7: Nomograms for Prostate Cancer Decision-Making Cesar E. Ercole, Michael W. Kattan, and Andrew J. Stephenson   8: Genetic Determinants of Familial and Hereditary Prostate Cancer Jesse K. McKenney,  Christopher G. Przybycin, and Cristina Magi-Galluzzi   9: New Molecular Markers of Diagnosis and Prognosis  in Prostate Cancer Rajal B. Shah and Ritu Bhalla   10: Intraoperative Consultation for Prostate Tumors: Challenges and Implications for Treatment Hiroshi Miyamoto and Steven S. Shen   11: Genomics and Epigenomics of Prostate Cancer Juan Miguel Mosquera, Pei-Chun Lin, and Mark A. Rubin       Part II: Update on Bladder Tumor Pathology     12: Anatomy of the Urinary Bladder Revisited:  Implications for Diagnosis and Staging of  Bladder Cancer Victor E. Reuter   13:  Classification and Histologic Grading of Urothelial Neoplasms by the WHO 2004 (ISUP 1998) Criteria Jesse K. McKenney   14:  Reporting of Bladder Cancer in TURBT and Cystectomy Specimens Jesse K. McKenney   15: Urothelial Carcinoma Variants:  Morphology and Association with Outcomes Gladell P. Paner  and Donna E. Hansel   16: Independent Predictors of Clinical Outcomes and Prediction Models on Bladder and Upper Urinary Tract Cancer Maria Carmen Mir, Andrew J. Stephenson, and Michael W. Kattan   17: Familial Urothelial Carcinomas Christopher G. Przybycin and Jesse K. McKenney   18: New Molecular Markers with Diagnostic and Prognostic Values in Bladder Cancer Hikmat A. Al-Ahmadie and Gopa Iyer   19: Intraoperative Consultation for Bladder Tumors: Challenges and Implications for Treatment Hiroshi Miyamoto and Steven S. Shen   20: Genetic and Epigenetic Alterations in Urothelial Carcinoma Hikmat A. Al-Ahmadie and Gopa Iyer   21: Urine Cytology Jordan P. Reynolds   Part III:  Update on Renal Tumor Pathology   22: Anatomy of the Kidney Revisited: Implications for Diagnosis and Staging of Renal Cell Carcinoma Stephen M. Bonsib   23: Classification of Adult Renal Tumors and Grading of Renal Cell Carcinoma William R. Sukov and John C. Cheville     24:  Tumor Staging for Renal Pathology Stephen M. Bonsib   25:  Surgical Pathology Reporting of Renal Cell Carcinomas Christopher G. Przybycin, Angela Wu, and Lakshmi P. Kunju   26: Newly Described Entities in Renal Tumor Pathology Angela Wu, Christopher G. Przybycin, and Lakshmi P. Kunju   27: Clinical and Management Implications Associated with Histologic Subtypes of Renal Cell Carcinomas Maria Carmen Mir, Brian I. Rini, and Steven C. Campbell   28: Independent Predictors of Clinical Outcomes and Prediction Models for Renal Tumor Pathology Nils Kroeger, Daniel Y.C. Heng, and Michael W. Kattan   29:  Pathology of Inherited Forms of Renal Carcinoma Maria J. Merino   30: The Utility of Immunohistochemistry in the Differential Diagnosis of Renal Cell Carcinomas Ming Zhou and Fang-Ming Deng   31: Intraoperative Consultation for Renal Masses: Challenges and Implications for Treatment Hiroshi Miyamoto and Steven S. Shen   32: Genetic and Epigenetic Alterations in Renal Cell Carcinoma Fang-Ming Deng and Ming Zhou   33: Role of Needle Biopsy in Renal Masses: Past, Present, Future Ying-Bei Chen     Part IV: Update on Testicular Tumor Pathology       34: Anatomy of the Testis and Staging of its Cancers: Implications for Diagnosis   Daniel M. Berney and Thomas M. Ulbright       35: Classification of Testicular Tumors   Cristina Magi-Galluzzi and Thomas M. Ulbright     36: Testicular Cancer Reporting on Radical Orchiectomy and Retroperitoneal Lymph Node Dissection After Treatment Daniel M. Berney   37: Difficult or Newly Described Morphologic Entities in Testicular Neoplasia Daniel M. Berney and Thomas M. Ulbright   38: Clinical Implications of the Different Histologic Subtypes of Testicular Tumors Timothy G illigan   39: Familial Syndromes Associated with Testicular Tumors Jesse K. McKenney, Claudio Lizarralde, and Cristina Magi-Galluzzi   40: Molecular and Immunohistochemical Markers of Diagnostic and Prognostic Value in Testicular Tumors Victor E. Reuter   41: Intraoperative Consultation for Testicular Tumors: Challenges and Implications for Treatment Hiroshi Miyamoto and Steven S. Shen   42: Genetic and Epigenetic Alterations in Testicular Tumors Pallavi A. Patil and Cristina Magi-Galluzzi

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