Description
This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements. The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPa and CP), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design. Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics. Chapter 1. Synthesis and Characterization of nano Apicomplexan motility: A cellular perspective particles.- Chapter 2. Introduction: Gliding Motility- The model and the mechanism.- Chapter 3. Actin: The central ubiquitous player in the phenomenon.- Chapter 4. Formin: The multidomain elongator of polymer.- Chapter 5. Profilin: The associates of Formin.- Chapter 6. ADF (Actin Depolymerizing Factor): The breaker of the polymer in homeostasis.- Chapter 7. Cyclase associated protein (CAP): The silent worker.- Chapter 8. Capping Protein (CP): The formin competitor.- Chapter 9. Coronin: An Overview.- Chapter 10. Mathematical Model: A revelation of synergistic cross talks between the actin regulators.- Chapter 11. Evolution: The hallmarks of Gliding motility in apicomplexan.
